Yamaji S, Ishii K, Sasaki M, Mori T, Kitagaki H, Sakamoto S, Mori E
Division of Imaging Research and Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan.
Clin Nucl Med. 2000 Jan;25(1):11-6. doi: 10.1097/00003072-200001000-00003.
When the cerebral metabolic rate of glucose (CMRglc) is to be measured, arterial blood sampling is usually required for fluorine-18 fluorodeoxyglucose (FDG) and positron emission tomography (PET) studies. However, blood sampling is inconvenient because it requires several staff members and is invasive for patients.
To assess cerebral glucose metabolism by a noninvasive and simplified method, the authors used the standardized uptake value (SUV), which requires no input function or blood sampling. The study participants included 18 healthy volunteers (4 men and 14 women; mean +/- SD age, 68.2+/-6.3 years), 18 patients with mild Alzheimer's disease (AD) (4 men and 14 women; mean +/- SD age, 68.8+/-7.3 years), and 18 patients with moderate AD (5 men and 13 women, mean +/- SD age, 69.5+/-8.5 years). Regional CMRglc and regional cerebral SUV were measured in the three groups using FDG PET, and the correlation between global CMRglc and global SUV was estimated.
The correlation coefficients of global CMRglc and global SUV in the healthy volunteers, mild AD patients, and moderate AD patients were 0.82, 0.67, and 0.62, respectively. Compared with the healthy persons, the patients with mild AD showed significantly decreased CMRglc in the temporal, frontal, and parietal cortices, but they did not show significantly decreased SUV in any region. Patients with moderate AD had significantly decreased CMRglc in the temporal, frontal, occipital, parietal, and sensorimotor cortices and significantly decreased SUV in the temporal, frontal, occipital, and parietal cortices.
The SUV would be useful as a semiquantitative index of cerebral glucose metabolism only in healthy persons or those with mild AD.
在测量脑葡萄糖代谢率（CMRglc）时，氟-18氟脱氧葡萄糖（FDG）和正电子发射断层扫描（PET）研究通常需要采集动脉血样。然而，采血不方便，因为它需要多名工作人员，而且对患者具有侵入性。
为了通过非侵入性和简化方法评估脑葡萄糖代谢，作者使用了标准化摄取值（SUV），该值不需要输入函数或采血。研究参与者包括18名健康志愿者（4名男性和14名女性；平均±标准差年龄，68.2±6.3岁）、18名轻度阿尔茨海默病（AD）患者（4名男性和14名女性；平均±标准差年龄，68.8±7.3岁）和18名中度AD患者（5名男性和13名女性，平均±标准差年龄，69.5±8.5岁）。使用FDG PET测量三组的区域CMRglc和区域脑SUV，并估计整体CMRglc和整体SUV之间的相关性。
健康志愿者、轻度AD患者和中度AD患者的整体CMRglc与整体SUV的相关系数分别为0.82、0.67和0.62。与健康人相比，轻度AD患者在颞叶、额叶和顶叶皮质的CMRglc显著降低，但在任何区域的SUV均未显著降低。中度AD患者在颞叶、额叶、枕叶、顶叶和感觉运动皮质的CMRglc显著降低，在颞叶、额叶、枕叶和顶叶皮质的SUV显著降低。
SUV仅在健康人或轻度AD患者中可用作脑葡萄糖代谢的半定量指标。
