Demirci F Y, Güney D B, Akarçay K, Kir N, Ozbek U, Sirma S, Unaltuna N, Ongör E
Department of Ophthalmology, Istanbul University, Istanbul Faculty of Medicine, Turkey.
Acta Ophthalmol Scand. 1999 Dec;77(6):631-3. doi: 10.1034/j.1600-0420.1999.770605.x.
Factor V Leiden mutation is a common genetic defect associated with a tendency to venous thrombosis. The aim of this study was to evaluate the prevalence of factor V Leiden in patients with retinal vein occlusion (RVO).
Blood samples were obtained from fifty RVO patients and were tested for factor V Leiden using DNA analysis. Twenty-three patients had central RVO (CRVO), twenty-five had branch RVO (BRVO) and two had CRVO in one eye and BRVO in the other eye.
DNA analysis showed that only 4 patients (8%) were heterozygous carriers of factor V Leiden. None of the patients were found to be homozygous. In the control group 11 (9.2%) were heterozygous carriers of factor V Leiden. The difference between the patients and the controls was not statistically significant.
There was no clear association between RVO and factor V Leiden in this pool of patients. Factor V Leiden does not seem to play an important role in the development of RVO.
凝血因子V莱顿突变是一种与静脉血栓形成倾向相关的常见基因缺陷。本研究的目的是评估视网膜静脉阻塞（RVO）患者中凝血因子V莱顿的患病率。
从50例RVO患者中采集血样，采用DNA分析检测凝血因子V莱顿。23例患者为中央视网膜静脉阻塞（CRVO），25例为分支视网膜静脉阻塞（BRVO），2例一只眼为CRVO，另一只眼为BRVO。
DNA分析显示，只有4例患者（8%）是凝血因子V莱顿的杂合子携带者。未发现患者为纯合子。在对照组中，11例（9.2%）是凝血因子V莱顿的杂合子携带者。患者与对照组之间的差异无统计学意义。
在这群患者中，RVO与凝血因子V莱顿之间没有明显关联。凝血因子V莱顿似乎在RVO的发生发展中不起重要作用。
