Zou Yuanyuan, Zhang Xi, Zhang Jingyi, Ji Xiangning, Liu Yuqing
The Second Department of Ophthalmology, Cangzhou Central Hospital, 061001, Cangzhou, PR China.
Oncotarget. 2017 Sep 4;8(43):75467-75477. doi: 10.18632/oncotarget.20636. eCollection 2017 Sep 26.
We performed a meta-analysis to investigate the association between the Factor V G1691A polymorphism and the risk of retinal vein occlusion (RVO). This analysis included 37 studies involving 2,510 cases and 3,466 controls. Factor V G1691A was associated with an increased risk of RVO in the allele, heterozygote, dominant, and carrier models (A < 0.001, odds ratios >1), but not the homozygote or recessive models (A > 0.05). Similar results were observed in a meta-analysis of central retinal vein occlusion (CRVO) and when comparing Caucasian subgroups to population-based controls. These data demonstrate that the G/A genotype of Factor V G1691A is associated with an increased risk of RVO/CRVO in a Caucasian population.
我们进行了一项荟萃分析，以研究凝血因子V G1691A多态性与视网膜静脉阻塞（RVO）风险之间的关联。该分析纳入了37项研究，涉及2510例病例和3466例对照。在等位基因、杂合子、显性和携带者模型中，凝血因子V G1691A与RVO风险增加相关（A<0.001，比值比>1），但在纯合子或隐性模型中无此关联（A>0.05）。在视网膜中央静脉阻塞（CRVO）的荟萃分析以及将白种人亚组与基于人群的对照进行比较时，也观察到了类似结果。这些数据表明，在白种人群中，凝血因子V G1691A的G/A基因型与RVO/CRVO风险增加相关。
