Ozbek N, Yetgin S, Tuncer A M
Pediatric Hematology Unit, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Leuk Res. 2000 Jan;24(1):55-8. doi: 10.1016/s0145-2126(99)00138-1.
Several agents, used either alone or in combination, have been shown to boost absolute numbers of PMLs and CD34+ stem cells in PB. In this study, we compared the effects of three different treatments, G-CSF, HDMP, and G-CSF + HDMP, for neutropenic patients (absolute PML count < 0.5 x 10(9)/l) who were on maintenance therapy for ALL with a control group who received no treatment. Hematological parameters, PB-CD34+33- and -CD34+ HLA-DR- stem cell numbers, and serum IL-3 levels were measured prior to, and a week after, the first day of treatment. WBC and absolute PML counts were significantly increased compared to pretreatment values in all treatment groups. However, peripheral CD34+ 33- and CD34+ HLA-DR stem cell numbers and serum IL-3 levels were increased significantly only in the G-CSF group. There was also a significant increase in serun IL-3 levels in the G-CSF + HDMP group. This study suggests that G-CSF may induce an increase in peripheral stem cell numbers, and that it supports hemopoietic recovery by increasing IL-3 in patients with chemotherapy-induced neutropenia.
单独或联合使用的几种药物已被证明可提高外周血中早幼粒细胞（PMLs）和CD34+干细胞的绝对数量。在本研究中，我们比较了三种不同治疗方法，即粒细胞集落刺激因子（G-CSF）、大剂量甲泼尼龙（HDMP）以及G-CSF + HDMP，对处于急性淋巴细胞白血病（ALL）维持治疗阶段的中性粒细胞减少患者（绝对PML计数<0.5×10⁹/L）的影响，并与未接受治疗的对照组进行比较。在治疗第一天之前及之后一周，测量血液学参数、外周血CD34+33-和CD34+HLA-DR-干细胞数量以及血清白细胞介素-3（IL-3）水平。与治疗前值相比，所有治疗组的白细胞（WBC）和绝对PML计数均显著增加。然而，仅G-CSF组外周血CD34+33-和CD34+HLA-DR干细胞数量以及血清IL-3水平显著增加。G-CSF + HDMP组血清IL-3水平也显著升高。本研究表明，G-CSF可能会诱导外周干细胞数量增加，并且通过增加化疗诱导的中性粒细胞减少患者的IL-3来支持造血恢复。
