Ozbek N, Yetgin S, Tuncer A M
Department of Pediatrics, School of Medicine, Başkent University, Ankara, Turkey.
Pediatr Hematol Oncol. 1998 Nov-Dec;15(6):539-44. doi: 10.3109/08880019809018316.
Treatment of neutropenia with corticosteroids and hemopoietic growth factors may cause alterations in the immune system. This study investigated and compared the effects of various regimens (HDMP, G-CSF, and G-CSF + HDMP) on total lymphocyte counts and subtypes in neutropenic patients with acute lymphoblastic leukemia. Lymphocyte subtypes were studied just prior to treatment and 1 week later. In the HDMP group, total lymphocyte counts and the numbers of CD3+, CD4+, CD8+, and CD19+ lymphocytes and monocytes increased, while the helper/suppressor lymphocyte ratio decreased. No significant changes were seen in lymphocyte subtypes in the G-CSF and G-CSF + HDMP groups, apart from an increase in total lymphocyte numbers. In the control group there was an increase in the number of CD3+ and CD8+ lymphocytes and a decrease in the helper/suppressor lymphocyte ratio. These results suggest that HDMP has an inducing, rather than a suppressive effect on all lymphocyte subtypes studied.
使用皮质类固醇和造血生长因子治疗中性粒细胞减少症可能会导致免疫系统发生改变。本研究调查并比较了各种治疗方案（大剂量甲泼尼龙[HDMP]、粒细胞集落刺激因子[G-CSF]以及G-CSF + HDMP）对急性淋巴细胞白血病中性粒细胞减少患者总淋巴细胞计数及淋巴细胞亚群的影响。在治疗前及治疗1周后对淋巴细胞亚群进行研究。在HDMP组中，总淋巴细胞计数以及CD3⁺、CD4⁺、CD8⁺、CD19⁺淋巴细胞和单核细胞数量增加，而辅助/抑制淋巴细胞比例下降。在G-CSF组和G-CSF + HDMP组中，除总淋巴细胞数量增加外，淋巴细胞亚群未见明显变化。在对照组中，CD3⁺和CD8⁺淋巴细胞数量增加，辅助/抑制淋巴细胞比例下降。这些结果表明，HDMP对所研究的所有淋巴细胞亚群具有诱导作用，而非抑制作用。
