Peron S, Tilly-Gentric A, Hutin P, Le Ninivin P, Le Goff P, Pennec Y L
Service de médecine interne et maladies infectieuses, Hôpital de la Cavale Blanche, CHU, Brest, France.
Rev Med Interne. 1999 Dec;20(12):1132-4. doi: 10.1016/s0248-8663(00)87528-1.
Polyarteritis nodosa is a disease process with a wide clinical spectrum, ranging from a severe generalized multisystem disorder to a more benign condition which may remain limited to the skin, muscles and peripheral nerves, and is termed cutaneous polyarteritis nodosa. Periosteal bone formation is uncommon in this condition.
We report two cases (two female patients of 80 and 55 years of age, respectively) who complained of red, tender nodules of legs and bone pain. Histological changes were those of necrotizing arteritis of the small and medium arteries in the panniculus and dermis. Bone X-ray showed periosteal bone formation.
In patients with pain, skin changes and swelling of the lower limbs, the diagnosis of periarteritis nodosa with periostitis has to be considered.
结节性多动脉炎是一种临床谱广泛的疾病过程，从严重的全身性多系统疾病到可能仅局限于皮肤、肌肉和周围神经的较为良性的状况，后者被称为皮肤型结节性多动脉炎。骨膜骨形成在这种疾病中并不常见。
我们报告两例病例（分别为80岁和55岁的女性患者），她们均主诉腿部出现红色压痛性结节及骨痛。组织学改变为皮下组织和真皮中小动脉的坏死性动脉炎。骨X线显示骨膜骨形成。
对于出现下肢疼痛、皮肤改变和肿胀的患者，必须考虑结节性多动脉炎合并骨膜炎的诊断。
