Sheptulin A A, Okhlobystin A V, Zain U A
Klin Med (Mosk). 1999;77(10):48-50.
Alkalizing effects of maalox, renni and tams were compared in 63 patients (27 males and 36 females) aged 19-56 with endoscopically confirmed superficial gastroduodenitis using intragastric pH-metry. Liquid antacids (maalox) began their action quicker (1.3-1.7 times) than tablets (renni and tams) but the tablets had longer alkalizing effects. Maximal and minimal alkalizing effects were achieved with maalox and renni, respectively. It is inferred that rapid intragastric pH-metry can be used for comparative assessment of different antacid drugs. Of the drugs studied the highest antiacid effect was exhibited by maalox.
采用胃内pH值测定法，对63例年龄在19至56岁之间、经内镜确诊为浅表性胃十二指肠炎症的患者（27例男性和36例女性）比较了氢氧化铝镁、雷尼替丁和泰胃美的碱化作用。液体抗酸剂（氢氧化铝镁）比片剂（雷尼替丁和泰胃美）起效更快（快1.3至1.7倍），但片剂的碱化作用持续时间更长。氢氧化铝镁和雷尼替丁分别达到最大和最小碱化作用。据推断，快速胃内pH值测定法可用于不同抗酸药物的比较评估。在所研究的药物中，氢氧化铝镁显示出最高的抗酸效果。
