Marriott I, Mason M J, Elhofy A, Bost K L
Department of Biology, University of North Carolina at Charlotte, 28223, USA.
J Neuroimmunol. 2000 Jan 24;102(2):163-71. doi: 10.1016/s0165-5728(99)00182-4.
Professional antigen presenting cells, such as macrophages, can be activated by intracellular calcium-dependent as well as calcium-independent mechanisms, depending upon the stimulus used. In this report, we addressed the mechanism of substance P-induced intracellular signalling in murine macrophages and dendritic cells. While no increases in intracellular calcium concentration were detected in macrophages or dendritic cells using sensitive fluorimetric techniques, substance P did induce rapid enhanced activation of NF-kappaB, a transcriptional activator known to regulate pro-inflammatory cytokines. These data provide an important mechanism by which substance P may augment the production of pro-inflammatory molecules.
专业抗原呈递细胞，如巨噬细胞，可根据所使用的刺激，通过细胞内钙依赖性和钙非依赖性机制被激活。在本报告中，我们探讨了P物质在小鼠巨噬细胞和树突状细胞中诱导细胞内信号传导的机制。虽然使用灵敏的荧光技术未在巨噬细胞或树突状细胞中检测到细胞内钙浓度的增加，但P物质确实诱导了核因子κB（NF-κB）的快速增强激活，NF-κB是一种已知可调节促炎细胞因子的转录激活因子。这些数据提供了一种重要机制，通过该机制P物质可能增加促炎分子的产生。
