Mishra Amrita, Lal Girdhari
National Centre for Cell Science (NCCS), SP Pune University Campus, Ganeshkhind, Pune, MH-411007, India.
Curr Res Immunol. 2021 Jul 1;2:66-78. doi: 10.1016/j.crimmu.2021.06.001. eCollection 2021.
Neurokinin receptors belong to the GPCRs family and are ubiquitously expressed throughout the nervous and immune systems. Neurokinin receptors in coordination with neurokinins playing an important role in many physiological processes, including smooth muscle contraction, secretion, proliferation, and nociception. They also contribute to various disease conditions such as inflammatory bowel disease, rheumatoid arthritis, multiple sclerosis, psoriasis, and cancer. Neurokinin receptors antagonist are potent and highly selective and showing success in treating chemotherapy-induced nausea and vomiting. In this review, discuss the various neurokinin receptor expression on immune cells and their importance in various inflammatory and autoimmune diseases and their therapeutic importance.
神经激肽受体属于G蛋白偶联受体家族，在整个神经和免疫系统中广泛表达。神经激肽受体与神经激肽协同作用，在许多生理过程中发挥重要作用，包括平滑肌收缩、分泌、增殖和痛觉感受。它们还与多种疾病状态有关，如炎症性肠病、类风湿性关节炎、多发性硬化症、银屑病和癌症。神经激肽受体拮抗剂具有强效和高度选择性，在治疗化疗引起的恶心和呕吐方面取得了成功。在这篇综述中，讨论了免疫细胞上各种神经激肽受体的表达及其在各种炎症和自身免疫性疾病中的重要性以及它们的治疗意义。
