Arkhipenko Iu V, Zhukova A G, Kizichenko N V, Tarakanov I A, Kozhevnikova L M
Patol Fiziol Eksp Ter. 1999 Oct-Dec(4):3-7.
To prevent disturbances of blood gas-transport function in hemorrhagic shock, we used cross-over protective effect of adaptation to short-term immobilization stress. Adaptation of rats to stress was associated with a rise in baseline arterial blood, pH in venous blood; fall in PO2, PCO2,P50. Stress-adapted rats appeared more resistant to blood loss. Gas transport 1 hour after hemorrhage was better than in non-adapted animals demonstrated more active compensatory reactions in l low hypoxic damage to the tissues. 2.5-h survival after start of bleeding in control animals made up 35%, in the group of adapted animals--67%. Thus, adaptation to short-term immobilization stress is a non-pharmacological method to prevent hemorrhagic shock.
为防止失血性休克时血气运输功能紊乱，我们采用了适应短期固定应激的交叉保护作用。大鼠对压力的适应与动脉血基线升高、静脉血pH值升高、PO2、PCO2、P50降低有关。适应应激的大鼠似乎对失血更有抵抗力。出血1小时后的气体运输情况优于未适应的动物，表明其对组织低氧损伤的代偿反应更活跃。对照动物出血开始后2.5小时的存活率为35%，适应应激的动物组为67%。因此，适应短期固定应激是一种预防失血性休克的非药物方法。
