Malyshev I Iu
Biull Eksp Biol Med. 1989 Apr;107(4):411-3.
Models of adrenergic arrhythmias were produced on isolated rat heart under the adrenalin concentration in the perfusion solution of 5.10(-5) M. The rhythm disturbances were accompanied by a pronounced depression of contractile function. It was shown that preliminary adaptation of animals to short-term stress exposures reduced the duration of arrhythmias more than sixfold the contractile function, being maintained at a higher level than in control. The adaptation cardioprotective effect was compared with the effects of adaptation and propranolol appeared similar.
在灌注液中肾上腺素浓度为5×10⁻⁵ M的条件下，在离体大鼠心脏上建立了肾上腺素能性心律失常模型。心律失常伴有明显的收缩功能抑制。结果表明，动物预先适应短期应激暴露可使心律失常持续时间缩短超过六倍，而收缩功能则维持在比对照组更高的水平。将适应性心脏保护作用与适应性和普萘洛尔的作用进行比较，发现它们相似。
