McDowell K M
Head, Section of Pediatric Pulmonology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
Respir Care Clin N Am. 2000 Mar;6(1):15-26. doi: 10.1016/s1078-5337(05)70055-1.
Asthma is a complex, multifactorial disease. Although airway reactivity, inflammation, and increased mucus secretion are agreed on universally as the central components of asthma, the pathophysiology of each of these is complex. This Article reviews the physiologic events resulting in symptoms of asthma. The contributions of genetics and environment to the development of the asthma phenotype are discussed. Gastroesophageal reflux and environmental allergies are prevalent conditions in asthmatic patients and often act as significant triggers for asthma symptoms.
哮喘是一种复杂的多因素疾病。尽管气道反应性、炎症和黏液分泌增加被普遍认为是哮喘的核心组成部分，但这些因素各自的病理生理学都很复杂。本文综述了导致哮喘症状的生理过程。文中还讨论了遗传和环境因素对哮喘表型形成的作用。胃食管反流和环境过敏在哮喘患者中很常见，并且常常是哮喘症状的重要触发因素。
