Morrione A
Kimmel Cancer Center, Thomas Jefferson University, 606 Bluemle Life Sciences Building, Philadelphia, PA 19107-5541, USA.
Int J Mol Med. 2000 Feb;5(2):151-4. doi: 10.3892/ijmm.5.2.151.
The adapter protein Grb10 belongs to a superfamily of related proteins that include Grb7, Grb14 and the Caenorhabtidis elegans Mig10. The available data on Grb10 proteins suggest a role of these adapters in signaling downstream of several receptor tyrosine kinases. In the present review the focus is on the interaction between Grb10 proteins and the insulin-like growth factor receptor/insulin receptor, and the role of Grb10 in IGF-I/insulin-induced mitogenesis is discussed, considering that the data available are also partially discordant.
衔接蛋白Grb10属于一个相关蛋白超家族，该超家族包括Grb7、Grb14和秀丽隐杆线虫Mig10。关于Grb10蛋白的现有数据表明，这些衔接蛋白在几种受体酪氨酸激酶的下游信号传导中发挥作用。在本综述中，重点是Grb10蛋白与胰岛素样生长因子受体/胰岛素受体之间的相互作用，并讨论了Grb10在IGF-I/胰岛素诱导的有丝分裂中的作用，鉴于现有数据也存在部分不一致。
