Morrione Andrea
Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
J Cell Physiol. 2003 Dec;197(3):307-11. doi: 10.1002/jcp.10363.
Grb10 is a member of a superfamily of adapter proteins that includes Grb10, 7, 14, and a protein of Caenorhabditis elegans called Mig10. Grb10 proteins are binding partners for several trans-membrane tyrosine-kinase receptors, including the insulin-like growth factor receptor (IGF-IR) and the insulin receptor (IR). Many recent reports have suggested a very important role of Grb10 in regulating IGF-IR signaling. In this review, we will focus on the role of Grb10 in IGF-I-induced mitogenesis and we will discuss the recent findings that show the involvement of Grb10 in the regulation of ligand-induced ubiquitination, internalization, and stability of the IGF-IR.
Grb10是衔接蛋白超家族的成员，该超家族包括Grb10、Grb7、Grb14以及秀丽隐杆线虫中的一种名为Mig10的蛋白。Grb10蛋白是几种跨膜酪氨酸激酶受体的结合伴侣，包括胰岛素样生长因子受体（IGF-IR）和胰岛素受体（IR）。最近许多报告表明Grb10在调节IGF-IR信号传导中起着非常重要的作用。在本综述中，我们将重点关注Grb10在IGF-I诱导的有丝分裂中的作用，并讨论最近的研究发现，这些发现表明Grb10参与了配体诱导的IGF-IR泛素化、内化和稳定性的调节。
