Chhabra S K, Khanduja A, Jain D
Department of Cardiorespiratory Physiology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi.
Indian J Chest Dis Allied Sci. 1999 Jan-Mar;41(1):15-26.
The activation of both the inflammation-producing cells and the airway smooth muscle in asthma is believed to be a phenomenon dependent on the intracellular calcium. The activity of Na+ K+ ATPase and Ca2+ ATPase, enzymes responsible for regulating the intracellular calcium concentrations has been reported to be decreased in asthma. An increase in plasma lysophosphatidylcholine (LPC), which is known to be a pro-inflammatory compound and has an inhibitory effect on the two ATPases has also been reported. Corticosteroids are potent antiinflammatory drugs very effective in the treatment of asthma. The effect of long-term (12 weeks) treatment with inhaled beclomethasone dipropionate (BDP) and short-term (1 week) treatment with oral prednisolone on the activity of the two ATPases and intracellular calcium in leukocytes and plasma LPC levels was investigated. Both the treatments resulted in an improvement in lung function accompanied by an increase in the activities of the ATPases and a decrease in the intracellular calcium and LPC levels. It was concluded that increase in the activities of Na+ K+ ATPase and Ca2+ ATPase and a consequent lowering of intracellular calcium, and a lowering of plasma LPC may underlie the beneficial effect of corticosteroids in asthma.
在哮喘中，产生炎症的细胞和气道平滑肌的激活被认为是一种依赖细胞内钙的现象。据报道，在哮喘中，负责调节细胞内钙浓度的酶——Na+K+ATP酶和Ca2+ATP酶的活性降低。也有报道称，血浆溶血磷脂酰胆碱（LPC）增加，已知其为一种促炎化合物，对这两种ATP酶有抑制作用。皮质类固醇是强效抗炎药物，对哮喘治疗非常有效。研究了吸入丙酸倍氯米松（BDP）长期（12周）治疗和口服泼尼松龙短期（1周）治疗对白细胞中两种ATP酶活性、细胞内钙以及血浆LPC水平的影响。两种治疗均使肺功能得到改善，同时ATP酶活性增加，细胞内钙和LPC水平降低。得出的结论是，Na+K+ATP酶和Ca2+ATP酶活性增加以及随之而来的细胞内钙降低，还有血浆LPC降低，可能是皮质类固醇对哮喘有益作用的基础。
