糖皮质激素的非基因组效应：最新观点。
Non-genomic Effects of Glucocorticoids: An Updated View.
机构信息
Department of Medicine, Rutgers Institute for Translational Medicine and Science, Robert Wood Johnson School of Medicine, New Brunswick, NJ, USA.
Science Impact, Winnipeg, Manitoba R3L 2S9, Canada.
出版信息
Trends Pharmacol Sci. 2019 Jan;40(1):38-49. doi: 10.1016/j.tips.2018.11.002. Epub 2018 Nov 26.
Abstract
Glucocorticoid (GC) anti-inflammatory effects generally require a prolonged onset of action and involve genomic processes. Because of the rapidity of some of the GC effects, however, the concept that non-genomic actions may contribute to GC mechanisms of action has arisen. While the mechanisms have not been completely elucidated, the non-genomic effects may play a role in the management of inflammatory diseases. For instance, we recently reported that GCs 'rapidly' enhanced the effects of bronchodilators, agents used in the treatment of allergic asthma. In this review article, we discuss (i) the non-genomic effects of GCs on pathways relevant to the pathogenesis of inflammatory diseases and (ii) the putative role of the membrane GC receptor. Since GC side effects are often considered to be generated through its genomic actions, understanding GC non-genomic effects will help design GCs with a better therapeutic index.
摘要
糖皮质激素（GC）的抗炎作用通常需要较长的作用时间，并涉及基因组过程。然而，由于 GC 作用的某些方面非常迅速，因此产生了非基因组作用可能有助于 GC 作用机制的概念。虽然这些机制尚未完全阐明，但非基因组作用可能在炎症性疾病的治疗中发挥作用。例如，我们最近报道 GC 可“迅速”增强支气管扩张剂（用于治疗过敏性哮喘的药物）的作用。在这篇综述文章中，我们讨论了（i）GC 对与炎症性疾病发病机制相关的途径的非基因组作用，以及（ii）膜 GC 受体的假定作用。由于 GC 的副作用通常被认为是通过其基因组作用产生的，因此了解 GC 的非基因组作用将有助于设计具有更好治疗指数的 GC。
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