Ong W Y, Yeo T T, Balcar V J, Garey L J
Department of Anatomy, National University of Singapore, Singapore.
J Neurocytol. 1998 Oct;27(10):719-30. doi: 10.1023/a:1006946717065.
Specimens of human cerebral cortex were obtained during neurosurgical operations and studied by immunocytochemistry and electron microscopy, using antibodies to the GABA transporter GAT-1. Cortical material from macaque monkeys was prepared similarly. Large numbers of GAT-1-positive non-pyramidal neurons were observed in layers I, II, V, and VI of the cortex. Electron microscopy also showed that the GAT-1-positive axon terminals formed symmetrical and not asymmetrical synapses, suggesting that they were the terminals of non-pyramidal neurons. Processes of cells in the walls of blood vessels were also labelled. We conclude that GAT-1 is present in cell bodies and axon terminals of non-pyramidal neurons, and a population of mural cells in blood vessels, in the primate cerebral cortex.
在神经外科手术过程中获取人类大脑皮层标本，并使用针对γ-氨基丁酸（GABA）转运体GAT-1的抗体，通过免疫细胞化学和电子显微镜进行研究。对猕猴的皮层材料也进行了类似的制备。在皮层的I、II、V和VI层中观察到大量GAT-1阳性的非锥体神经元。电子显微镜还显示，GAT-1阳性轴突终末形成的是对称而非不对称突触，这表明它们是非锥体神经元的终末。血管壁细胞的突起也被标记。我们得出结论，在灵长类动物大脑皮层中，GAT-1存在于非锥体神经元的细胞体和轴突终末以及血管中的一群壁细胞中。
