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A light and electron microscopic study of GAT-1 in the monkey basal ganglia.

作者信息

Wang X S, Ong W Y

机构信息

Department of Anatomy, National University of Singapore, Singapore 119260.

出版信息

J Neurocytol. 1999 Dec;28(12):1053-61. doi: 10.1023/a:1007056608820.

DOI:10.1023/a:1007056608820
PMID:11054905
Abstract

The distribution of the GABA transporter GAT-1 was studied by immunocytochemistry and electron microscopy in the monkey basal ganglia. Dense staining was observed in the globus pallidus externa and interna, intermediate in the subthalamic nucleus, and substantia nigra, and light staining in the caudate nucleus and putamen. Staining was observed in axon terminals, but not cell bodies. Electron microscopy showed that the GAT-1 positive axon terminals formed symmetrical synapses, suggesting that they were the terminals of GABAergic neurons. Comparison of areas high in GAT-1 protein with that of GABA showed a good correlation between the density in neuropil staining for GAT-1, and that of GABA.

摘要

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