论垂体在大鼠性别分化及肝脏代谢中的重要作用。
On the obligatory role of the hypophysis in sexual differentiation hepatic metabolism in rats.
作者信息
Gustafsson J A, Stenberg A
出版信息
Proc Natl Acad Sci U S A. 1976 May;73(5):1462-5. doi: 10.1073/pnas.73.5.1462.
The hepatic metabolism of 4-[4-14C]androstene-3,17-dione and 5alpha-[4-14C]androstane-3alpha,17beta-diol was studies in castrated and hypophysectomized male rats with a transplanted pituitary under the kidney capsule. The effects of testosterone propionate and estradiol benzoate on liver metabolism were also studied in these experimental animals. It was found that the autonomous pituitary secreted a "feminizing factor" that transformed the male type of steroid metabolism characteristic of hypophysectomized rats into a female type of metabolism Hypophysectomized rats were unresponsive towards androgen action on the liver and did not respond with feminized hepatic metabolism after treatment with estradiol benzoate. It is concluded that estrogenic action on liver enzymes is mediated via modulation of the secretion of a central (probably hypothalamic) "feminizing factor inhibiting factor" and the sex hormonal effects of hepatic metabolism only occur in the presence of a pituitary in situ.
在肾囊下移植有垂体的去势和垂体切除雄性大鼠中，研究了4-[4-¹⁴C]雄甾烯-3,17-二酮和5α-[4-¹⁴C]雄烷-3α,17β-二醇的肝脏代谢。还在这些实验动物中研究了丙酸睾酮和苯甲酸雌二醇对肝脏代谢的影响。发现自主垂体分泌一种“女性化因子”，它将垂体切除大鼠特有的雄性类固醇代谢类型转变为雌性代谢类型。垂体切除大鼠对雄激素对肝脏的作用无反应，用苯甲酸雌二醇处理后也不会出现雌性化的肝脏代谢反应。结论是，雌激素对肝脏酶的作用是通过调节中枢（可能是下丘脑）“女性化因子抑制因子”的分泌来介导的，并且肝脏代谢的性激素效应仅在原位存在垂体的情况下才会发生。
Zotero 插件