Gustafsson J A, Stenberg A
Endocrinology. 1975 Feb;96(2):501-4. doi: 10.1210/endo-96-2-501.
The metabolism of 4-(4014C)androstene-3,17-dione and 5alpha-(4-14C)androstene-3alpha, 17beta-diol was studies in the microsomal fraction and that of 4-(4-14C) androstene-3,17-dione in the 105,000 times g supernatant fraction of livers from castrated male and female rats treated with LH and FSH. Administration of LH led to significant decreases in 17-hydroxysteroid reduction and 7alpha-hydroxylation of 4-androstene-3,17-dione in both male and female rats and in 6beta-hydroxylation of 4-androstene-3,17-dione in female rats. FSH on the other hand specifically stimulated (masculinized) the following sex-dependent hydroxylations: 16alpha-hydroxylation of 4-androstene-3,17-dione in female rats and 2alpha-, and 2beta- and 18-hydroxylation of 5alpha-androstane-3alpha,17beta-diol in male rats. The metabolism of 4-androstene-3,17-dione and 5alpha-androstane-3alpha,17beta-diol was also studied in castrated male and female rats given testosterone propionate and in castrated female rats given testosterone propionate in combination with LH or FSH. It was shown that neither LH nor FSH could compensate for the relative androgen-unresponsiveness exhibited by female as compared to male rats. It is concluded that FSH but not LH may participate in the regulation of sex-dependent hydroxylase systems in rat liver.?2,Author
在微粒体部分研究了4-(4'-¹⁴C)雄甾烯-3,17-二酮和5α-(4-¹⁴C)雄甾烯-3α,17β-二醇的代谢，并在经促黄体生成素（LH）和促卵泡生成素（FSH）处理的去势雄性和雌性大鼠肝脏的105,000倍重力上清液部分研究了4-(4-¹⁴C)雄甾烯-3,17-二酮的代谢。给予LH导致雄性和雌性大鼠中4-雄甾烯-3,17-二酮的17-羟类固醇还原和7α-羟基化以及雌性大鼠中4-雄甾烯-3,17-二酮的6β-羟基化显著降低。另一方面，FSH特异性刺激（使男性化）以下性别依赖性羟基化：雌性大鼠中4-雄甾烯-3,17-二酮的16α-羟基化以及雄性大鼠中5α-雄甾烷-3α,17β-二醇的2α-、2β-和18-羟基化。还在给予丙酸睾酮的去势雄性和雌性大鼠以及给予丙酸睾酮与LH或FSH组合的去势雌性大鼠中研究了4-雄甾烯-3,17-二酮和5α-雄甾烷-3α,17β-二醇的代谢。结果表明，与雄性大鼠相比，LH和FSH均不能补偿雌性大鼠表现出的相对雄激素无反应性。得出的结论是，FSH而非LH可能参与大鼠肝脏中性别依赖性羟化酶系统的调节。作者
