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培养的人脐静脉平滑肌细胞中前列腺素E合成的刺激作用。

Stimulation of prostaglandin E synthesis in cultured human umbilical vein smooth muscle cells.

作者信息

Alexander R W, Gimbrone M A

出版信息

Proc Natl Acad Sci U S A. 1976 May;73(5):1617-20. doi: 10.1073/pnas.73.5.1617.

DOI:10.1073/pnas.73.5.1617
PMID:1064032
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC430350/
Abstract

Cultured human umbilical vein smooth muscle cells secreted 1.26 +/- 0.20 mug of immunoreactive prostaglandin E (iPGE) per mg of cell protein per 24 hr (mean +/- SEM). In indomethacin, an inhibitor of prostaglandin synthesis, abolished greater than 95% of this basal iPGE production (ID50 = 1.8 nM).

摘要

培养的人脐静脉平滑肌细胞每毫克细胞蛋白每24小时分泌1.26±0.20微克免疫反应性前列腺素E（iPGE）（平均值±标准误）。前列腺素合成抑制剂吲哚美辛可消除超过95%的基础iPGE分泌（半数抑制浓度=1.8纳摩尔）。

相似文献

1
Stimulation of prostaglandin E synthesis in cultured human umbilical vein smooth muscle cells.培养的人脐静脉平滑肌细胞中前列腺素E合成的刺激作用。
Proc Natl Acad Sci U S A. 1976 May;73(5):1617-20. doi: 10.1073/pnas.73.5.1617.
2
Angiotensin II stimulation of prostaglandin production in cultured human vascular endothelium.血管紧张素II对培养的人血管内皮细胞中前列腺素生成的刺激作用。
Science. 1975 Jul 18;189(4198):219-20. doi: 10.1126/science.1138377.
3
Effect of indomethacin and prostaglandin on the smooth muscle contracting activity of angiotensin and other agonists.吲哚美辛和前列腺素对血管紧张素及其他激动剂平滑肌收缩活性的影响。
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Inhibition of bradykinin vasodilation and potentiation of norepinephrine and angiotensin vasoconstriction by inhibitors of prostaglandin synthesis in skeletal muscle of the rat.前列腺素合成抑制剂对大鼠骨骼肌中缓激肽血管舒张作用的抑制及去甲肾上腺素和血管紧张素血管收缩作用的增强
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5
Effects of vasoactive agents on isolated human umbilical arteries and veins.血管活性药物对离体人脐动脉和静脉的作用。
Am J Physiol. 1972 Feb;222(2):345-55. doi: 10.1152/ajplegacy.1972.222.2.345.
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Contractile responses of the guinea-pig trachea in vitro: modification by prostaglandin synthesis-inhibiting drugs.豚鼠气管体外收缩反应：前列腺素合成抑制药物的影响
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Studies of prostaglandins and prostaglandin antagonists on bovine pulmonary vein in vitro.前列腺素及前列腺素拮抗剂对牛肺静脉的体外研究。
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Some properties of prostaglandin E1 action on muscle.前列腺素E1对肌肉作用的一些特性。
Arch Int Pharmacodyn Ther. 1967 Oct;169(2):328-41.
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Evidence for enhanced venous smooth muscle turnover of prostaglandin-like substance in portal veins from spontaneously hypertensive rats.自发性高血压大鼠门静脉中类前列腺素物质的静脉平滑肌更新增强的证据。
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Pharmacology of colonic muscle.结肠肌肉的药理学
Gut. 1975 Apr;16(4):307-11. doi: 10.1136/gut.16.4.307.

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Patent ductus arteriosus: experimental aspects.动脉导管未闭：实验研究方面
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本文引用的文献

1
Prostaglandin levels in normal and transformed baby-hamster-kidney fibroblasts.正常及转化的幼仓鼠肾成纤维细胞中的前列腺素水平。
Nat New Biol. 1973 May 9;243(123):50-1.
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
3
Significance of phospholipase A for prostaglandin formation.磷脂酶A对前列腺素形成的意义。
Ann N Y Acad Sci. 1971 Apr 30;180:123-5. doi: 10.1111/j.1749-6632.1971.tb53191.x.
4
Prostaglandin production by mouse fibrosarcoma cells in culture: inhibition by indomethacin and aspirin.培养的小鼠纤维肉瘤细胞中前列腺素的产生：吲哚美辛和阿司匹林的抑制作用
Biochem Biophys Res Commun. 1972 May 26;47(4):888-96. doi: 10.1016/0006-291x(72)90576-1.
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Differential effect of noradrenaline and renal nerve stimulation on vascular resistance in the dog kidney and the release of a prostaglandin E-like substance.
Clin Sci. 1972 Feb;42(2):223-33. doi: 10.1042/cs0420223.
6
The release of prostaglandins and rabbit aorta contracting substance (RCS) from rabbit spleen and its antagonism by anti-inflammatory drugs.前列腺素和兔主动脉收缩物质（RCS）从兔脾脏中的释放及其被抗炎药物的拮抗作用。
Br J Pharmacol. 1972 May;45(1):37-47. doi: 10.1111/j.1476-5381.1972.tb09574.x.
7
Effects of vasoactive agents on isolated human umbilical arteries and veins.血管活性药物对离体人脐动脉和静脉的作用。
Am J Physiol. 1972 Feb;222(2):345-55. doi: 10.1152/ajplegacy.1972.222.2.345.
8
Distribution of prostaglandins E1,E2, F1-alpha and F2-alpha in some animal tissues.
J Pharm Pharmacol. 1968 Oct;20(10):749-53. doi: 10.1111/j.2042-7158.1968.tb09633.x.
9
Microcirculatory effects of prostaglandins E1, E2, and A1 in the rat mesentery and cremaster muscle.前列腺素E1、E2和A1对大鼠肠系膜和提睾肌的微循环影响。
Microvasc Res. 1974 Jul;8(1):77-89. doi: 10.1016/0026-2862(74)90066-1.
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Effects of prostaglandin synthesis inhibitors on angiotensin tachyphylaxis in the isolated coeliac and mesenteric arteries of the rabbit.
Pol J Pharmacol Pharm. 1974 Jan-Apr;26(1):217-27.