血管紧张素II对培养的人血管内皮细胞中前列腺素生成的刺激作用。

Angiotensin II stimulation of prostaglandin production in cultured human vascular endothelium.

作者信息

Gimbrone M A, Alexander R W

出版信息

Science. 1975 Jul 18;189(4198):219-20. doi: 10.1126/science.1138377.

Abstract

Immunoreactive material resembling prostaglandin E accumulates in the medium of cultured human umbilical vein endothelial cells. Prodcution is inhibited by indomethacin and stimulated by angiotensin II. Prostaglandin secretion by endothelium may be important in platelet-dependent thrombotic phenomena, and in local control of vascular permeability and tone in vivo.

摘要

类似于前列腺素E的免疫反应性物质在培养的人脐静脉内皮细胞培养基中积聚。其产生受吲哚美辛抑制，受血管紧张素II刺激。内皮细胞分泌前列腺素在血小板依赖性血栓形成现象以及体内血管通透性和张力的局部控制中可能很重要。