Danö P, Stadil F
Scand J Gastroenterol Suppl. 1976;37:93-7.
In a retrospective study the basal and food-stimulated serum concentrations of gastrin and gastric secretion of acid were studied in 28 patients following three types of intestinal shunt operation for obesity. In each type 48 cm of functioning small intestine was preserved, but the ratio between functioning jejunum and ileum was different. The basal and stimulated concentrations of gastrin in serum were significantly higher in patients with the shortest jejunum in function. There was no difference in the gastric acid output. The study suggests that gastrin participates in evoking the gastric hypersecretion of acid which follows massive bowel resection or bypass. Deprivation of a hormonal inhibitory substance from the upper jejunum may be responsible for the increased serum gastrin concentration.
在一项回顾性研究中，对28例接受三种类型肥胖症肠道分流手术的患者，研究了胃泌素的基础和食物刺激血清浓度以及胃酸分泌情况。每种类型都保留了48厘米的功能性小肠，但功能性空肠和回肠之间的比例不同。功能最短空肠的患者血清中胃泌素的基础和刺激浓度显著更高。胃酸分泌量没有差异。该研究表明，胃泌素参与引发大量肠切除或肠旁路术后的胃酸分泌过多。来自上 jejunum的一种激素抑制物质的缺乏可能是血清胃泌素浓度升高的原因。 （注：原文中“jejunum”拼写有误，正确拼写为“空肠”，译文已修正）
