Mikkelsen J D, Jensen J B, Engelbrecht T, Mørk A
Department of Neurobiology, H. Lundbeck A/S, Copenhagen-Valby, Denmark.
Brain Res. 1999 Dec 18;851(1-2):247-51. doi: 10.1016/s0006-8993(99)01953-8.
Activation of serotonin neurotransmission produces increase of plasma oxytocin, prolactin, vasopressin and ACTH levels. Using dual-immunocytochemistry, the number of oxytocinergic neurons in the hypothalamic magnocellular nuclei co-storing Fos after administration of D-fenfluramine was found to be 15-fold higher compared to vehicle, comprising about 30% of the total number of these neurons. Vasopressinergic neurons were virtually not affected. These results show that serotonergic neurotransmission induces Fos transcription in oxytocinergic neurons that may lead to a release of oxytocin to the general circulation, whereas vasopressinergic neurons are activated through another mechanism.
血清素神经传递的激活会导致血浆中催产素、催乳素、血管加压素和促肾上腺皮质激素水平升高。使用双重免疫细胞化学方法发现，给予D-芬氟拉明后，下丘脑大细胞神经核中共同储存Fos的催产素能神经元数量比给予赋形剂时高15倍，约占这些神经元总数的30%。血管加压素能神经元几乎未受影响。这些结果表明，血清素能神经传递诱导催产素能神经元中的Fos转录，这可能导致催产素释放到全身循环中，而血管加压素能神经元则通过另一种机制被激活。
