Oriani G, Salvatori G, Maiorano G, Manchisi A, Brienza A, Pantaleo L, Di Caterina R, Rotunno T
Dipartimento di Scienze Animali Vegetali e dell'Ambiente, Università degli Studi del Molise, Campobasso, Italy.
Int J Vitam Nutr Res. 1999 Nov;69(6):378-84. doi: 10.1024/0300-9831.69.6.378.
The effects of intramuscularly administrated vitamin E on total lipids, fatty acid profile, and lipid stability to oxidation was investigated in lamb liver. Twenty-four 5-day-old lambs were allotted to 4 groups of 6 each and given respectively 0 (control), 125, 200, 300 mg dl-alpha-tocopheryl acetate weekly from day 5 to 33. alpha-Tocopherol stored in lamb liver at the end of experiment showed linear correlation with the level of injected vitamin E. No effect on total lipids was found. A decrease in the level of liver thiobarbituric-acid reactive substances (TBARS), significantly correlated with liver alpha-tocopherol content, was found in vitamin E groups. The amount of linoleic and linolenic acids significantly increased in the vitamin E groups as compared to control group, and were correlated with the liver alpha-tocopherol content. TBARS were negatively correlated with the concentration of unsaturated fatty acids. Finally, in the liver of the treated groups, vitamin E concentrations in the range 30-50 micrograms/g showed adequate for an efficient protection from peroxidation of membrane lipids, and determined an increase in the unsaturated to saturated fatty acid ratio.
研究了肌肉注射维生素E对羔羊肝脏总脂质、脂肪酸谱以及脂质氧化稳定性的影响。将24只5日龄羔羊分为4组，每组6只，从第5天到第33天每周分别给予0（对照组）、125、200、300毫克的dl-α-生育酚醋酸酯。实验结束时，羔羊肝脏中储存的α-生育酚与注射的维生素E水平呈线性相关。未发现对总脂质有影响。在维生素E组中，发现肝脏硫代巴比妥酸反应性物质（TBARS）水平降低，且与肝脏α-生育酚含量显著相关。与对照组相比，维生素E组中亚油酸和亚麻酸的含量显著增加，且与肝脏α-生育酚含量相关。TBARS与不饱和脂肪酸浓度呈负相关。最后，在处理组的肝脏中，维生素E浓度在30 - 50微克/克范围内显示足以有效保护膜脂质免受过氧化，并导致不饱和脂肪酸与饱和脂肪酸的比例增加。
