[The effect of the cultivation conditions on the properties of bacilli comprising the basis of probiotics].

Such biological factors as bile, gastric juice, blood serum, amino acids and pH of the medium have been studied for their effect on the growth intensity and antagonistic activity of bacilli being the basis of biosporin and subalin. It has been established that pH of the medium within 7.0-9.0 as well as certain concentrations of the gastric juice, bile, blood serum and most of amino acids did not affect the growth of Bacillus subtilis 3 and Bacillus subtilis 2335/105. A regular decrease of growth intensity in bacilli under the increase of the gastric juice concentration or decrease of pH of the medium to 5.0-2.0 is registered. The mentioned biological factors affect differently the antagonistic properties of the studied cultures.