Sidbury R, Heintz P W, Beckstead J H, White C R
Department of Dermatology, Oregon Health Sciences University, Portland, USA.
Adv Dermatol. 1999;14:285-306.
In summary, cutaneous malignancies with an epithelioid appearance form a diverse group of neoplasms that may be difficult to diagnose by utilizing routine microscopy alone. Cutaneous malignancies, including malignant melanoma and metastatic carcinoma, certain benign neoplasms such as mixed tumor of the skin and angiolymphoid hyperplasia with eosinophils (epithelioid hemangioma), and infectious conditions such as bacillary (epithelioid) angiomatosis can be considered in this differential. However, through recognition of the characteristic histologic, immunocytochemical, and ultrastructural findings outlined above, definitive diagnosis of these challenging neoplasms is usually possible.
总之，具有上皮样外观的皮肤恶性肿瘤构成了一组多样的肿瘤，仅通过常规显微镜检查可能难以诊断。鉴别诊断时可考虑包括恶性黑色素瘤和转移性癌在内的皮肤恶性肿瘤、某些良性肿瘤，如皮肤混合瘤和伴有嗜酸性粒细胞的血管淋巴样增生（上皮样血管瘤），以及感染性疾病，如杆菌性（上皮样）血管瘤病。然而，通过识别上述特征性的组织学、免疫细胞化学和超微结构表现，通常可以对这些具有挑战性的肿瘤做出明确诊断。
