Brodie C, Provenzano E
Department of Histopathology, University College Hospital, Galway, Ireland.
Histopathology. 2008 Jan;52(1):30-44. doi: 10.1111/j.1365-2559.2007.02892.x.
Vascular proliferations of the breast are uncommon but potentially diagnostically challenging lesions. Clinically apparent processes are more likely to be malignant; however, a range of benign entities which must be differentiated from angiosarcoma also exists. This review discusses first, breast lesions of apparent vascular origin, then benign and histologically bland perilobular, cavernous and capillary haemangiomas. Subsequently, more diagnostically challenging, atypical haemangiomas, papillary endothelial hyperplasia, angiomatosis and angiolymphoid hyperplasia with eosinophilia (epithelioid haemangioma) are considered. In addition, lesions with low-grade malignant potential such as haemangiopericytomas and epithelioid haemangioendotheliomas may rarely present in the breast. However, primary angiosarcomas and radiation-associated vascular lesions are reviewed in depth, as these entities are of greatest clinical and pathological significance.
乳腺血管增生并不常见，但在诊断上可能具有挑战性。临床上明显的病变更有可能是恶性的；然而，也存在一系列必须与血管肉瘤相鉴别的良性病变。本综述首先讨论明显起源于血管的乳腺病变，然后是良性且组织学表现温和的小叶周围、海绵状和毛细血管瘤。随后，将考虑更具诊断挑战性的非典型血管瘤、乳头状内皮增生、血管瘤病和伴有嗜酸性粒细胞的血管淋巴样增生（上皮样血管瘤）。此外，具有低度恶性潜能的病变，如血管外皮细胞瘤和上皮样血管内皮瘤，在乳腺中可能很少出现。然而，原发性血管肉瘤和与放疗相关的血管病变将进行深入综述，因为这些病变具有最大的临床和病理意义。
