Versino M, Beltrami G, Uggetti C, Cosi V
Dipartimento Scienze Neurologiche, Università di Pavia, Italy.
J Neurol Neurosurg Psychiatry. 2000 Feb;68(2):234-7. doi: 10.1136/jnnp.68.2.234.
Visual and auditory saccades were studied in three patients with an isolated lesion located in the central thalamus. Visual saccades proved to be normal, whereas for auditory stimuli, the amplitude of the first saccade was asymmetric: saccades ipsilateral to the lesion were significantly smaller than those directed to the contralateral side. The patients were able to make a corrective saccade and hence to improve gain and to decrease gain asymmetry. It is suggested that patients were able to localise auditory targets correctly, but did not correctly take into account eye position during the saccade, probably as a consequence of an inaccurate efference copy (corollary discharge) signal. The findings are in keeping with the hypothesis that the central thalamus deals with saccades that are based on extraretinal signals.
对三名丘脑中央孤立性病变患者的视觉和听觉扫视进行了研究。结果表明，视觉扫视正常，而对于听觉刺激，首次扫视的幅度不对称：病变同侧的扫视明显小于对侧的扫视。患者能够进行矫正性扫视，从而提高增益并减少增益不对称。这表明患者能够正确定位听觉目标，但在扫视过程中没有正确考虑眼睛位置，这可能是传出副本（推论放电）信号不准确的结果。这些发现与丘脑中央处理基于视网膜外信号的扫视这一假设相符。
