Iwama T, Utsunomiya J, Hamaguchi E
Bull Tokyo Med Dent Univ. 1975 Jun;22(2):151-4.
It is said that the Paneth cells are found in the large intestine in a pathological state such as ulcerative colitis or adenoma. We examined the Paneth cells in the adenomas of familial polyposis coli. Nine cases including one case of Gardner's syndrome comprised the material for the examination of the Paneth cells because the caecum was available for the examination. The remaining one case had no Paneth cells. In two cases, the Paneth cells were found among the adenomas in the areas beyond the caecum and the proximal part of the colon ascendens. In one remarkable case, the Paneth cells were found in 43% of the adenomas in the caecum. Seven cases were carcinomas but no Paneth cells were found in or near the carcinoma. In the control cases, which were taken from the resected colon with a disease other than familial polyposis coli, the Paneth cells were found confined to the caecum. We concluded that the distribution of the Paneth cell-bearing adenomas reflects the distribution of the Paneth cells in the normal mucosa of the large intestine and that the Paneth cells in the adenoma may have differentiated in the adenoma.
据说潘氏细胞在溃疡性结肠炎或腺瘤等病理状态下会出现在大肠中。我们检查了家族性腺瘤性息肉病腺瘤中的潘氏细胞。包括1例加德纳综合征病例在内的9例病例构成了潘氏细胞检查的材料，因为盲肠可用于检查。其余1例没有潘氏细胞。在2例病例中，在盲肠和升结肠近端以外区域的腺瘤中发现了潘氏细胞。在1例显著的病例中，在盲肠43%的腺瘤中发现了潘氏细胞。7例为癌，但在癌组织内或其附近未发现潘氏细胞。在取自患有除家族性腺瘤性息肉病以外疾病的切除结肠的对照病例中，发现潘氏细胞仅局限于盲肠。我们得出结论，含潘氏细胞腺瘤的分布反映了大肠正常黏膜中潘氏细胞的分布，并且腺瘤中的潘氏细胞可能已在腺瘤中分化。
