Keplinger M L, Lyman F L, Calandra J C
Environ Qual Saf Suppl. 1975;4:205-12.
Compounds (1), (2), (3), and (4) caused no adverse toxic effects and yielded no evidence of carcinogenic activity in a 2-year feeding study in albino rats at dietary levels up to 1000 ppm. Compounds (2), (3) and (4) were without effect in a 2-year study in beagle dogs at levels up to 2000 ppm. Compound (1) at levels of 400 and 1000 ppm led to decreased weight gains in some dogs and caused doserelated pathology consisting of inflammatory changes on the serosal surfaces of abdominal viscera and increased hematopoietic acitivty of the spleen and liver cords. These effect could have been due to the feeding of material, without adjustment of pH, for the first 30 weeks of the study.
化合物（1）、（2）、（3）和（4）在一项对白化大鼠进行的为期两年的喂养研究中，在高达1000 ppm的膳食水平下未产生不良毒性作用，也未显示出致癌活性的证据。化合物（2）、（3）和（4）在一项对小猎犬进行的为期两年的研究中，在高达2000 ppm的水平下没有影响。化合物（1）在400 ppm和1000 ppm的水平下导致一些狗体重增加减少，并引起与剂量相关的病理学变化，包括腹部内脏浆膜表面的炎症改变以及脾脏和肝索造血活性增加。这些影响可能是由于在研究的前30周喂养未经pH调节的物质所致。
