使用全氟烷基物质进行的三代生殖研究。

Three-generation Reproduction studies with FWAs.

作者信息

Keplinger M L, Lyman F L, Calandra J C

出版信息

Environ Qual Saf Suppl. 1975;4:230-8.

Abstract

Four fluorescent whitening agents (FWAs), compounds (1), (2), (3) and (4) (see table 1) were investigated for their effects on the reproductive performance of albino rats through 3 successive 2-litter generations at dietary levels of 40, 200, and 1000 ppm. Except for slight and random effects of compound (4) on pup survival, no adverse effects were observed. The random effects with compound (4) were not consistently related to either dose level or cumulative duration of exposure through the 3 generations.

摘要

研究了四种荧光增白剂（FWAs），即化合物（1）、（2）、（3）和（4）（见表1），通过连续三代、每代两窝白化大鼠，在饮食水平分别为40、200和1000 ppm的情况下，对其生殖性能的影响。除化合物（4）对幼崽存活率有轻微随机影响外，未观察到不良影响。化合物（4）的随机影响与剂量水平或三代暴露的累积持续时间均无一致关联。