Oliva B, Comanducci A, Chopra I
Department of Experimental Medicine, University of L'Aquila, Italy.
Tuber Lung Dis. 1998;79(2):107-9. doi: 10.1054/tuld.1998.0012.
The mechanism of action of many antimycobacterial agents is poorly understood. To obtain preliminary information on whether the targets for some of these drugs might also occur in other bacteria, the in vitro activities of selected agents against Escherichia coli, Bacillus subtilis and Staphylococcus aureus were determined. Dapsone, p-aminosalicylic acid and thiacetazone failed to inhibit the above organisms (MIC values > 100 micrograms/ml) that may therefore lack targets for these drugs. Capreomycin, viomycin and clofazimine demonstrated activity against some of the organisms (MIC values < 100 micrograms/ml) suggesting that the targets of these drugs may not be restricted to mycobacterial species. The agents were all potent inhibitors of Mycobacterium bovis bacille Calmette-Guérin (MIC values 0.08-0.5 microgram/ml).
许多抗分枝杆菌药物的作用机制尚不清楚。为了获取关于这些药物的某些靶点是否也存在于其他细菌中的初步信息，测定了所选药物对大肠杆菌、枯草芽孢杆菌和金黄色葡萄球菌的体外活性。氨苯砜、对氨基水杨酸和硫乙腙未能抑制上述微生物（最低抑菌浓度值>100微克/毫升），因此这些微生物可能缺乏这些药物的靶点。卷曲霉素、紫霉素和氯法齐明对某些微生物表现出活性（最低抑菌浓度值<100微克/毫升），这表明这些药物的靶点可能并不局限于分枝杆菌属。这些药物都是牛型结核分枝杆菌卡介苗的强效抑制剂（最低抑菌浓度值0.08 - 0.5微克/毫升）。
