黄果悬钩子中疏水氧杂蒽酮对枯草芽孢杆菌和耐甲氧西林金黄色葡萄球菌的抗菌活性

Antimicrobial activity of hydrophobic xanthones from Cudrania cochinchinensis against Bacillus subtilis and methicillin-resistant Staphylococcus aureus.

作者信息

Fukai Toshio, Oku Yukio, Hou Ai-Jun, Yonekawa Makiko, Terada Sumio

机构信息

Department of Biophysical Chemistry, School of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan.

出版信息

Chem Biodivers. 2004 Sep;1(9):1385-90. doi: 10.1002/cbdv.200490101.

DOI:10.1002/cbdv.200490101

PMID:17191916

Abstract

Ten xanthones with one or two isoprenoid groups and a prenylated benzophenone isolated from roots of Cudrania cochinchinensis (Moraceae) were tested for their antimicrobial activities against Bacillus subtilis and methicillin-resistant Staphylococcus aureus (MRSA). Among these compounds, gerontoxanthone H exhibited considerable antibacterial activity against B. subtilis (MIC = 1.56 microg/ml). Four xanthones, gerontoxanthone I, toxyloxanthone C, cudraxanthone S, and 1,3,7-trihydroxy-2-prenylxanthone, showed weak antibacterial activity against the bacterium (MICs = 3.13-6.25 microg/ml). These compounds also exhibited similar MIC values against methicillin-sensitive S. aureus, MRSAs, and Micrococcus luteus.

摘要

从桑科植物构棘的根部分离得到了十种含有一个或两个异戊二烯基的呫吨酮以及一种异戊烯基化二苯甲酮，并测试了它们对枯草芽孢杆菌和耐甲氧西林金黄色葡萄球菌（MRSA）的抗菌活性。在这些化合物中，老年呫吨酮H对枯草芽孢杆菌表现出相当强的抗菌活性（MIC = 1.56微克/毫升）。四种呫吨酮，即老年呫吨酮I、毒氧呫吨酮C、构棘呫吨酮S和1,3,7-三羟基-2-异戊烯基呫吨酮，对该细菌表现出较弱的抗菌活性（MICs = 3.13 - 6.25微克/毫升）。这些化合物对甲氧西林敏感金黄色葡萄球菌、耐甲氧西林金黄色葡萄球菌和藤黄微球菌也表现出相似的MIC值。