Pollono F, Pollmeier M, Rossi L
Merck Research Laboratories, Germany.
Parassitologia. 1998 Dec;40(4):457-9.
This trial was conducted to test the efficacy of ivermectin/pyrantel chewables in preventing the development of Dirofilaria repens in dogs. The trial included 155 dogs from an endemic area in North-Western Italy. Prior to enrollment in the study, none of the dogs had microfilariae of D. immitis or D. repens in a concentration test, and all dogs were also seronegative for adult heartworm antigen. Animals remained with their owners and were dosed six times, at monthly intervals according to body weight. Efficacy against D. repens was evaluated approximately 6 and 12 months after the first dosing. None of the treated dogs was found to harbour microfilariae of D. repens or D. immitis on either occasion, whereas 6 of 24 untreated controls had circulating D. repens microfilariae at the final testing. The treatment was well accepted by all dogs.
进行该试验是为了测试伊维菌素/噻嘧啶咀嚼片预防犬恶丝虫在犬体内发育的效果。试验纳入了来自意大利西北部一个流行地区的155只犬。在纳入研究之前，所有犬在浓度检测中均未发现犬恶丝虫或匐行恶丝虫的微丝蚴，并且所有犬的成年心丝虫抗原血清学检测也均为阴性。动物与主人一起饲养，并根据体重每月给药一次，共给药六次。在首次给药后约6个月和12个月评估对匐行恶丝虫的疗效。在这两个时间点，未发现任何一只接受治疗的犬体内有匐行恶丝虫或犬恶丝虫的微丝蚴，而在最终检测时，24只未治疗的对照犬中有6只出现了循环的匐行恶丝虫微丝蚴。所有犬对该治疗的接受度良好。
