Marconcini A, Magi M, Contin B H
Dipartimento di Patologia Animale, Profilassi e Igiene degli Alimenti Università degli Studi di Pisa.
Parassitologia. 1993 Dec;35(1-3):67-71.
The ability of ivermectin to control canine dirofilariosis in naturally infected dogs was tested. Two studies were carried out in the coast line of Grosseto district (Italy), where D. repens infection is endemic. A sample of 384 dogs from the area was examined as background controls and we found D. repens in 21.1%, D. immitis in 7.8% and both species in 6.5%. In the first study we used 72 privately-owned dogs, of varying sex, breed and age; all animals were negative to Knott's modified test for microfilariae and to CITE test for the adult antigens. All the dogs were treated monthly per os with tablets of ivermectin (> or = 6 mcg/kg) seven times from May 1991. All dogs were found negative for microfilariae 6-8 months after the last treatment. The second experiment was carried out on 16 Beagles aged 5.5-7 months (8 control dogs and 8 treated dogs). The dogs lived in a semi-open kennel in the selected area. We treated 8 dogs--8 times at monthly intervals, starting in June--with ivermectin tablets per os (> or = 6 mcg/kg). The monthly examination for circulating microfilariae (Knott's modified test) showed D. repens in two control dogs 7 months after the beginning of the experiment, one month later in 6 control and in another control animal also positive for D. immitis between the 10th and 11th month. Treated dogs were always negative. At the necropsy of all the dogs, about 11 months after the beginning of the experiment, we found adults or pre-adults of filariae in all the control dogs. Four animals had a double infection, 3 with D. repens and one with D. immitis. We never found adults or pre-adults of filariae in treated dogs.
对伊维菌素控制自然感染犬类心丝虫病的能力进行了测试。在意大利格罗塞托地区的海岸线开展了两项研究，该地是匐行恶丝虫感染的流行区。对该地区的384只犬样本进行检查作为背景对照，我们发现感染匐行恶丝虫的犬占21.1%，感染犬恶丝虫的犬占7.8%，同时感染两种丝虫的犬占6.5%。在第一项研究中，我们使用了72只不同性别、品种和年龄的家养犬；所有动物对改良Knott氏微丝蚴检测及成体抗原CITE检测均呈阴性。从1991年5月起，所有犬每月口服伊维菌素片剂（≥6 mcg/kg），共7次。在最后一次治疗后6 - 8个月，所有犬的微丝蚴检测均呈阴性。第二项实验在16只5.5 - 7月龄的比格犬身上进行（8只对照犬和8只治疗犬）。这些犬生活在选定区域的半开放式犬舍中。我们从6月开始，每月给8只犬口服伊维菌素片剂（≥6 mcg/kg），共8次。每月进行循环微丝蚴检查（改良Knott氏检测），结果显示，实验开始7个月后，2只对照犬感染了匐行恶丝虫，1个月后，6只对照犬感染了匐行恶丝虫，另一只对照犬在第10至11个月同时感染了犬恶丝虫。治疗犬始终呈阴性。在实验开始约11个月后对所有犬进行尸检时，我们在所有对照犬体内发现了丝虫成虫或未成熟成虫。4只动物为双重感染，3只感染匐行恶丝虫，1只感染犬恶丝虫。在治疗犬体内从未发现丝虫成虫或未成熟成虫。
