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双相情感障碍和精神分裂症中的皮纹分析——“精神病连续体”假说得到证实了吗?

Dermatoglyphic analysis in bipolar affective disorder and schizophrenia--"continuum of psychosis" hypothesis corroborated?

作者信息

Jelovac N, Milicić J, Milas M, Dodig G, Turek S, Ugrenović Z

机构信息

Psychiatric Clinic, University of Split, Croatia.

出版信息

Coll Antropol. 1999 Dec;23(2):589-95.

PMID:10646232
Abstract

Dermatoglyphic features are thought to be indicators of events in the early embryonal stages. They might also be associated with the developmental disorders of the central nervous system (CNS) including schizophrenia. Dermatoglyphic features of 92 male patients with bipolar affective disorder (BPAD) (unipolar depression and schizoaffective psychosis were excluded from the study) were compared with those of 195 males with schizophrenia (SCH) and both with those of 200 male controls (control group-CG). DSM-III-R criteria were used for the diagnostic evaluation. Quantitative analysis showed only one statistically significant difference between BPAD and SCH patients groups, regarding the c-d ridge count of the left hand. The canonical discriminant analysis did not permit correct classification (only 59.23% of cases were correctly classified) between BPAD and SCH. Numerous quantitative dermatoglyphic features of both BPAD and SCH differed significantly from those of the control subjects. Finger ridge counts as well as palmar ridge counts were markedly lower in BPAD and SCH as compared to the controls. These findings are not in contradiction with the hypothesis claiming that psychoses are a set of diverse expressions (due also to noninherited factors) of a single underlying entity.

摘要

皮纹特征被认为是胚胎早期事件的指标。它们也可能与包括精神分裂症在内的中枢神经系统(CNS)发育障碍有关。将92名双相情感障碍(BPAD)男性患者(该研究排除了单相抑郁症和精神分裂症性精神病患者)的皮纹特征与195名精神分裂症(SCH)男性患者以及200名男性对照者(对照组-CG)的皮纹特征进行了比较。诊断评估采用DSM-III-R标准。定量分析显示,BPAD组和SCH组患者之间仅在左手c-d嵴纹计数方面存在一个具有统计学意义的差异。典型判别分析无法对BPAD和SCH进行正确分类(仅59.23%的病例被正确分类)。BPAD和SCH的许多定量皮纹特征与对照受试者的特征有显著差异。与对照组相比,BPAD和SCH患者的指纹嵴计数和掌纹嵴计数明显更低。这些发现与认为精神病是单一潜在实体的一组不同表现(也由于非遗传因素)的假设并不矛盾。

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