Saha Sukanta, Loesch Danuta, Chant David, Welham Joy, El-Saadi Ossama, Fañanás Lourdes, Mowry Bryan, McGrath John
Queensland Centre for Schizophrenia Research, The Park Centre for Mental Health, Wacol, Qld 4076, Australia.
BMC Psychiatry. 2003 Mar 23;3:3. doi: 10.1186/1471-244x-3-3.
Several studies have reported alterations in finger and a-b ridge counts, and their derived measures of asymmetry, in schizophrenia compared to controls. Because ridges are fully formed by the end of the second trimester, they may provide clues to disturbed early development. The aim of this study was to assess these measures in a sample of patients with psychosis and normal controls.
Individuals with psychosis (n = 240), and normal controls (n = 228) were drawn from a catchment-area case-control study. Differences in finger and a-b ridge count and Fluctuating Asymmetry were assessed in three group comparisons (non-affective psychosis versus controls; affective psychosis versus controls; non-affective psychosis versus affective psychosis). The analyses were performed separately for males and females.
There were no significant group differences for finger nor a-b ridge counts. While there were no group difference for Directional Asymmetry, for Fluctuating Asymmetry measures men with non-affective psychosis had significantly higher fluctuating asymmetry of the index finger ridge count (a) when compared to controls (FA-correlation score, p = 0.02), and (b) when compared to affective psychosis (adjusted FA-difference score, p = 0.04).
Overall, measures of finger and a-b ridge counts, and their derived measures of directional and fluctuating asymmetry were not prominent features of psychosis in this sample. While directional asymmetry in cerebral morphology is reduced in schizophrenia, this is not reflected in dermatoglyphic variables.
多项研究报告称，与对照组相比，精神分裂症患者的手指嵴纹计数及a-b嵴纹计数及其不对称性衍生指标存在改变。由于嵴纹在妊娠中期结束时就已完全形成，它们可能为早期发育紊乱提供线索。本研究的目的是在一组精神病患者样本和正常对照组中评估这些指标。
从一项集水区病例对照研究中选取精神病患者（n = 240）和正常对照组（n = 228）。在三组比较中评估手指和a-b嵴纹计数以及波动不对称性的差异（非情感性精神病与对照组；情感性精神病与对照组；非情感性精神病与情感性精神病）。分析分别针对男性和女性进行。
手指和a-b嵴纹计数在组间无显著差异。虽然方向性不对称在组间无差异，但对于波动不对称性指标，非情感性精神病男性的食指嵴纹计数波动不对称性（a）与对照组相比显著更高（FA相关评分，p = 0.02），（b）与情感性精神病相比也显著更高（调整后的FA差异评分，p = 0.04）。
总体而言，手指和a-b嵴纹计数及其方向性和波动不对称性衍生指标在该样本中并非精神病的突出特征。虽然精神分裂症患者大脑形态的方向性不对称性降低，但这在皮纹变量中并未体现。
