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本文引用的文献

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Expression of DNA repair proteins hMSH2, hMSH6, hMLH1, O6-methylguanine-DNA methyltransferase and N-methylpurine-DNA glycosylase in melanoma cells with acquired drug resistance.
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Reduced activity of topoisomerase II in an Adriamycin-resistant human stomach-adenocarcinoma cell line.阿霉素耐药的人胃腺癌细胞系中拓扑异构酶II活性降低。
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Human melanoma cell lines selected in vitro displaying various levels of drug resistance against cisplatin, fotemustine, vindesine or etoposide: modulation of proto-oncogene expression.在体外筛选出的对顺铂、福莫司汀、长春地辛或依托泊苷具有不同耐药水平的人黑色素瘤细胞系：原癌基因表达的调节
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Mechanism of action of topoisomerase II-targeted antineoplastic drugs.拓扑异构酶II靶向抗肿瘤药物的作用机制。
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Single-strand conformational polymorphism analysis of the M(r) 170,000 isozyme of DNA topoisomerase II in human tumor cells.人类肿瘤细胞中DNA拓扑异构酶II的170,000分子量同工酶的单链构象多态性分析
Cancer Res. 1993 Mar 15;53(6):1373-9.
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Characterization of an unusual mutant of human melanoma cells resistant to anticancer drugs that inhibit topoisomerase II.一种对抑制拓扑异构酶II的抗癌药物具有抗性的人类黑色素瘤细胞异常突变体的特征分析。
J Cell Physiol. 1993 May;155(2):414-25. doi: 10.1002/jcp.1041550224.
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A novel mutant topoisomerase II alpha present in VP-16-resistant human melanoma cell lines has a deletion of alanine 429.
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9
Proliferation-associated nuclear antigen Ki-S1 is identical with topoisomerase II alpha. Delineation of a carboxy-terminal epitope with peptide antibodies.增殖相关核抗原Ki-S1与拓扑异构酶IIα相同。用肽抗体描绘羧基末端表位。
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10
Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide.抗肿瘤药物作用机制：4'-（9-吖啶基氨基）-间甲氧基甲磺酰苯胺对哺乳动物DNA拓扑异构酶II在DNA上的毒害作用。
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获得性耐药黑色素瘤细胞中DNA拓扑异构酶II活性及表达的调控

Modulation of DNA topoisomerase II activity and expression in melanoma cells with acquired drug resistance.

作者信息

Lage H, Helmbach H, Dietel M, Schadendorf D

机构信息

Institute of Pathology, Charité, Humboldt University Berlin, Germany.

出版信息

Br J Cancer. 2000 Jan;82(2):488-91. doi: 10.1054/bjoc.1999.0947.

DOI:10.1054/bjoc.1999.0947
PMID:10646909
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2363299/
Abstract

The role of DNA topoisomerases (Topo) IIalpha and IIbeta was investigated in various drug-resistant melanoma cells. Melanoma cells resistant to etoposide, exhibited an up to tenfold reduced Topo II activity corresponding to an increasing degree of drug resistance indicating that modulation of Topo II activity contribute to the drug-resistant phenotype. The reduction of Topo II activity was reflected by decreased nuclear amounts of both Topo II isoforms.

摘要

在各种耐药性黑色素瘤细胞中研究了DNA拓扑异构酶（Topo）IIα和IIβ的作用。对依托泊苷耐药的黑色素瘤细胞，其Topo II活性降低了多达10倍，这与耐药程度的增加相对应，表明Topo II活性的调节促成了耐药表型。Topo II活性的降低表现为两种Topo II亚型的核含量减少。