得克萨斯州艾森豆中具有抗菌和抗真菌活性的黄烷酮类化合物。

Antibacterial and antifungal flavanones from Eysenhardtia texana.

作者信息

Wächter G A, Hoffmann J J, Furbacher T, Blake M E, Timmermann B N

机构信息

Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson 85706, USA.

出版信息

Phytochemistry. 1999 Dec;52(8):1469-71. doi: 10.1016/s0031-9422(99)00221-6.

DOI:10.1016/s0031-9422(99)00221-6

PMID:10647219

Abstract

An activity-guided fractionation of a methanol-dichloromethane extract obtained from the aerial parts of Eysenhardtia texana led to the isolation of two novel antibacterial and antifungal flavanones together with a known flavanone. Their structures were established as 4',5,7-trihydroxy-8-methyl-6-(3-methyl-[2-butenyl])-(2S)-flavanone, 4',5,7-trihydroxy-6-methyl-8-(3-methyl-[2-butenyl])-(2S)-flavanone and 4',5-dihydroxy-7-methoxy-6-(3-methyl-[2-butenyl])-(2S)-flavanone on the basis of their UV, 1D and 2D-NMR spectra.

摘要

对得克萨斯州艾森豪蒂亚（Eysenhardtia texana）地上部分的甲醇 - 二氯甲烷提取物进行活性导向分级分离，得到了两种新型抗菌和抗真菌黄烷酮以及一种已知黄烷酮。根据它们的紫外光谱、一维和二维核磁共振谱，确定它们的结构分别为4',5,7 - 三羟基 - 8 - 甲基 - 6 - (3 - 甲基 - [2 - 丁烯基]) - (2S) - 黄烷酮、4',5,7 - 三羟基 - 6 - 甲基 - 8 - (3 - 甲基 - [2 - 丁烯基]) - (2S) - 黄烷酮和4',5 - 二羟基 - 7 - 甲氧基 - 6 - (3 - 甲基 - [2 - 丁烯基]) - (2S) - 黄烷酮。