来自印度枳椇茎皮的抗菌成分。

Antimicrobial constituents from the stem bark of Feronia limonia.

作者信息

Rahman Md Mukhlesur, Gray Alexander I

机构信息

Department of Pharmaceutical Sciences, University of Strathclyde, SIBS Building, 27 Taylor Street, G4 ONR, Glasgow, UK.

出版信息

Phytochemistry. 2002 Jan;59(1):73-7. doi: 10.1016/s0031-9422(01)00423-x.

DOI:10.1016/s0031-9422(01)00423-x

PMID:11754947

Abstract

The stem bark of Feronia limonia (Fam. Rutaceae) yielded (-)-(2S)-5,3'-dihydroxy-4'-methoxy-6",6"-dimethylchromeno-(7,8,2",3")-flavanone along with several known compounds including an alkaloid, five coumarins, a flavanone, a lignan, three sterols and a triterpene. The structures of these compounds were determined by spectroscopic methods, mainly 1D and 2D NMR. The antimicrobial screening of compounds by a microdilution technique resulted in MICs in the range 25-100 microg/ml. Other biological activities of the known compounds are also discussed.

摘要

柠檬叶花椒（芸香科）的茎皮产生了（-）-（2S）-5,3'-二羟基-4'-甲氧基-6",6"-二甲基色原烯并[7,8,2",3"]-黄烷酮以及几种已知化合物，包括一种生物碱、五种香豆素、一种黄烷酮、一种木脂素、三种甾醇和一种三萜。这些化合物的结构通过光谱方法确定，主要是一维和二维核磁共振。通过微量稀释技术对化合物进行抗菌筛选，结果显示最低抑菌浓度在25 - 100微克/毫升范围内。还讨论了已知化合物的其他生物活性。