Aboody Mohammed Saleh Al, Mickymaray Suresh
Department of Biology, College of Science, Al-Zulfi, Majmaah University, Riyadh region, Majmaah 11952, Saudi Arabia.
Antibiotics (Basel). 2020 Jan 26;9(2):45. doi: 10.3390/antibiotics9020045.
The prevalence of fungal infections is growing at an alarming pace and the pathogenesis is still not clearly understood. Recurrence of these fungal diseases is often due to their evolutionary avoidance of antifungal resistance. The development of suitable novel antimicrobial agents for fungal diseases continues to be a major problem in the current clinical field. Hence, it is urgently necessary to develop surrogate agents that are more effective than conventional available drugs. Among the remarkable innovations from earlier investigations on natural-drugs, flavonoids are a group of plant-derived substances capable of promoting many valuable effects on humans. The identification of flavonoids with possible antifungal effects at small concentrations or in synergistic combinations could help to overcome this problem. A combination of flavonoids with available drugs is an excellent approach to reduce the side effects and toxicity. This review focuses on various naturally occurring flavonoids and their antifungal activities, modes of action, and synergetic use in combination with conventional drugs.
真菌感染的患病率正以惊人的速度增长，其发病机制仍未完全明确。这些真菌疾病的复发往往是由于它们在进化过程中产生了抗真菌耐药性。开发适用于真菌疾病的新型抗菌药物仍然是当前临床领域的一个主要问题。因此，迫切需要开发比传统可用药物更有效的替代药物。在早期对天然药物的研究中，黄酮类化合物是一类从植物中提取的物质，对人体有许多有益作用。鉴定出在低浓度或协同组合时可能具有抗真菌作用的黄酮类化合物，有助于解决这一问题。黄酮类化合物与现有药物联合使用是减少副作用和毒性的绝佳方法。本综述重点关注各种天然存在的黄酮类化合物及其抗真菌活性、作用方式以及与传统药物的协同应用。
