实验性氯气肺损伤后立即吸入皮质类固醇的效果。

Effects of inhalation of corticosteroids immediately after experimental chlorine gas lung injury.

作者信息

Gunnarsson M, Walther S M, Seidal T, Lennquist S

机构信息

Department of Surgery, University Hospital, Linköping, Sweden.

出版信息

J Trauma. 2000 Jan;48(1):101-7. doi: 10.1097/00005373-200001000-00017.

DOI:10.1097/00005373-200001000-00017

PMID:10647573

Abstract

BACKGROUND

To assess the effects of treatment with nebulized corticosteroids immediately after chlorine gas injury.

METHODS

Eighteen anesthetized and mechanically ventilated pigs were exposed to chlorine gas (140 ppm for 10 minutes) and observed for 6 hours. Nine pigs were treated with nebulized beclomethasone-dipropionate 20 microg/kg (BDP group), and nine pigs were given no treatment (control group).

RESULTS

All animals developed severe pulmonary dysfunction. The initial decrease in PaO2 was similar in both groups, but BDP-treated animals improved whereas control animals deteriorated (p < 0.005; analysis of variance). Pulmonary vascular resistance increased in both groups but less in the BDP group (p < 0.01). Lung-thorax compliance was better preserved in the BDP group (p < 0.01), and oxygen delivery was significantly better in the BDP group (p < 0.01). One animal died in the BDP group, as did three animals in the control group.

CONCLUSION

Immediate treatment with nebulized BDP improved pulmonary and cardiovascular function after experimental chlorine gas injury.

摘要

背景

评估氯气损伤后立即雾化吸入皮质类固醇的治疗效果。

方法

18只麻醉并机械通气的猪暴露于氯气（140 ppm，持续10分钟），观察6小时。9只猪接受雾化吸入二丙酸倍氯米松20 μg/kg治疗（BDP组），9只猪未接受治疗（对照组）。

结果

所有动物均出现严重肺功能障碍。两组动物初始PaO2下降相似，但BDP治疗组动物情况改善，而对照组动物情况恶化（p < 0.005；方差分析）。两组肺血管阻力均增加，但BDP组增加较少（p < 0.01）。BDP组肺胸顺应性保存较好（p < 0.01），BDP组氧输送明显更好（p < 0.01）。BDP组有1只动物死亡，对照组有3只动物死亡。