体外培养的具有不同恶性程度的小鼠A9细胞克隆：与YACIR淋巴瘤细胞克隆进行体细胞杂交分析
In vitro derived mouse A9 cell clones differing in malignancy: analysis by somatic cell hybridization with YACIR lymphoma cell clones.
作者信息
Clements G B, Fenyö E M, Klein G
出版信息
Proc Natl Acad Sci U S A. 1976 Jun;73(6):2004-7. doi: 10.1073/pnas.73.6.2004.
Abstract
A culture of mouse A9 cells yielded clones of both high and low malignancy. Confirmation of the differences in malignancy of the clones was obtained after their hybridization with subclones of YACIR a lymphoma induced by Moloney leukemia virus. Low malignant A9 clones suppressed the malignancy of the YACIR partner in the hybrids. Hybrids between a highly malignant A9 cline and two different clones of YACIR "complemented" to yield hybrids of reduced malignancy. No correlation was formed between the malignancy of a particular A9 clone and its ability to produce a focus-forming mouse C-type virus.
摘要
小鼠A9细胞的培养产生了高恶性和低恶性的克隆。这些克隆与由莫洛尼白血病病毒诱导的淋巴瘤YACIR的亚克隆杂交后，证实了克隆之间恶性程度的差异。低恶性的A9克隆抑制了杂交体中YACIR伙伴的恶性程度。高恶性A9克隆与YACIR的两个不同克隆之间的杂交“互补”，产生了恶性程度降低的杂交体。特定A9克隆的恶性程度与其产生集落形成小鼠C型病毒的能力之间没有相关性。
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