Tsujimoto Y, Shimizu S
Department of Medical Genetics, Biomedical Research Center, Osaka University Graduate School of Medicine, CREST of Japan Science and Technology Corp. (JST), 2-2 Yamadaoka, Suita, Osaka, Japan.
FEBS Lett. 2000 Jan 21;466(1):6-10. doi: 10.1016/s0014-5793(99)01761-5.
The Bcl-2 family of proteins that consists of anti-apoptotic and pro-apoptotic members determines life-or-death of a cell by controlling the release of mitochondrial apoptogenic factors, cytochrome c and apoptosis-inducing factor (AIF), that activate downstream executional phases, including the activation of death proteases called caspases. Cytochrome c release is, thus, central to apoptotic signal transduction in mammals, making study of the mechanism for cytochrome c release a major issue. Several models for cytochrome c release have been proposed, including rupture of mitochondrial outer membrane and involvement of a specific channel. Here, we provide an overview of recent findings on the role of Bcl-2 family members in the life-or-death decision of a cell.
由抗凋亡和促凋亡成员组成的Bcl-2蛋白家族，通过控制线粒体凋亡因子、细胞色素c和凋亡诱导因子（AIF）的释放来决定细胞的生死，这些因子会激活下游的执行阶段，包括激活称为半胱天冬酶的死亡蛋白酶。因此，细胞色素c的释放是哺乳动物凋亡信号转导的核心，使得对细胞色素c释放机制的研究成为一个主要问题。已经提出了几种细胞色素c释放的模型，包括线粒体外膜破裂和特定通道的参与。在这里，我们概述了关于Bcl-2家族成员在细胞生死抉择中作用的最新发现。
