Ekenved G, Norrby A, Sölvell L
Scand J Haematol Suppl. 1976;28:31-49. doi: 10.1111/j.1600-0609.1976.tb00347.x.
The correlation between the magnitude of the increase of serum iron after an oral dose of iron and the total absorption of iron was studied in 51 healthy subjects and 10 patients with iron deficiency anaemia. 59Fe-labelled solutions of ferrous sulphate (25-100 mg iron) were administered to the fasting subjects. The serum iron concentration was followed for 4-6 hours and the absorption was measured in a whole-body counter. Good correlation was found between the maximal increase of serum iron and the total amount of iron absorbed after a dose of iron given as a solution. The serum iron method may be used for comparisons of the absorbability of different doses of iron by performing cross-over studies in groups of subjects. However, it was found that in an individual subject the serum iron method could not be used to determine the amount of iron absorbed from an oral dose of iron.
在51名健康受试者和10名缺铁性贫血患者中，研究了口服铁剂后血清铁增加幅度与铁的总吸收量之间的相关性。向空腹受试者给予硫酸亚铁的59Fe标记溶液（25 - 100毫克铁）。跟踪血清铁浓度4 - 6小时，并在全身计数器中测量吸收情况。发现给予溶液形式铁剂后血清铁的最大增加量与吸收的铁总量之间存在良好的相关性。血清铁方法可用于通过在受试者组中进行交叉研究来比较不同剂量铁的吸收能力。然而，发现对于个体受试者，血清铁方法不能用于确定口服铁剂后吸收的铁量。
