Beard M, Gauci C, Sikora E, Kirk B, Fairley G H, Wrigley P
Scand J Haematol. 1976 Apr;16(4):258-62. doi: 10.1111/j.1600-0609.1976.tb01147.x.
24 patients with Philadelphia chromosome positive chronic myeloid leukaemia (CML) in blast crisis were treated with intensive chemotherapy. 16 patients showed either partial or complete response to this treatment, but median survival remained short (13 weeks), and much of this time was spent in hospital. These results were not significantly better than those obtained by others using vincristine and prednisolone alone, and this combination of drugs can often be given on an outpatient basis. It is concluded that until more effective intensive therapy becomes available patients in CML blast crisis should be managed in such a way that the quality of life is not impaired; and that at present vincristine and prednisolone appears to be the most impaired; and that at present vincristine and prednisolone appears to be the most appropriate initial treatment, though even this is far from satisfactory.
24例费城染色体阳性的慢性粒细胞白血病（CML）急变期患者接受了强化化疗。16例患者对该治疗有部分或完全反应，但中位生存期仍然较短（13周），且大部分时间都在住院。这些结果并不比其他人单独使用长春新碱和泼尼松龙所获得的结果明显更好，而且这种药物组合通常可以在门诊给药。得出的结论是，在有更有效的强化治疗方法之前，CML急变期患者的管理方式应确保生活质量不受损害；目前长春新碱和泼尼松龙似乎是最受影响的；目前长春新碱和泼尼松龙似乎是最合适的初始治疗方法，尽管即便如此也远不能令人满意。
