Kano Y, Takaku F, Sakamoto S, Hida K, Kasahara T, Okamura J, Hasegawa K, Tsukada T, Sasaki H
Scand J Haematol. 1981 Nov;27(5):323-6. doi: 10.1111/j.1600-0609.1981.tb00492.x.
6 cases of chronic myelogenous leukaemia (CML) blast crisis in childhood were treated with vincristine and prednisolone (V-P). In 3 terminal transferase ((TdT)-positive cases, blast cells were lymphoid in appearance. All 3 TdT-positive patients entered a complete remission but developed meningeal leukaemia. The mean duration of survival from the onset of blast crisis was 32 months. In 3 TdT-negative cases, V-P therapy was ineffective. The results of this study suggest that V-P therapy is more effective for CML blast crisis in childhood with TdT positive blast cells and that prophylactic central nervous system treatment is necessary to prevent meningeal leukaemia.
