Durán-Patrón R, Aleu J, Hernández-Galán R, Collado I G
Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Cádiz, Apdo. 40, 11510 Puerto Real, Cádiz, Spain.
J Nat Prod. 2000 Jan;63(1):44-7. doi: 10.1021/np990296q.
Biotransformation of (4E,8R)-caryophyll-4(5)-en-8-ol (1) with Botrytis cinerea afforded 14 products (3-16). Thirteen of these (4-16) are described here for the first time. The main reaction paths involved the isomerization of the double bond at C-4/C-5 and hydroxylation of methyl groups.
