Departamento de Química Orgánica, Facultad de Ciencias, Campus Universitario Río San Pedro s/n, Torre sur, 4a planta, Universidad de Cádiz, 11510, Puerto Real, Cádiz, Spain.
Departamento de Química Orgánica, Facultad de Ciencias, Campus Universitario Río San Pedro s/n, Torre sur, 4a planta, Universidad de Cádiz, 11510, Puerto Real, Cádiz, Spain; Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, 14040-903 Ribeirão Preto, Brazil.
Phytochemistry. 2018 Oct;154:10-18. doi: 10.1016/j.phytochem.2018.06.010. Epub 2018 Jun 19.
A thorough study of the fermentation broth of three strains of Botrytis cinerea which were grown on a modified Czapek-Dox medium supplemented with 5 ppm copper sulphate, yielded five undescribed metabolites. These metabolites possessed a sesquiterpenoid (+)-4-epi-eremophil-9-ene carbon skeleton which was enantiomeric to that of the phytoalexin, capsidiol. The isolation of these metabolites when the fungus was stressed, suggests that they may be potential effectors used by B. cinerea to circumvent plant chemical defences against phytopathogenic fungi. The biosynthesis of these compounds has been studied using H and C labelled acetate.
对在添加了 5ppm 硫酸铜的改良 Czapek-Dox 培养基上生长的三株 Botrytis cinerea 菌株的发酵液进行了深入研究，从中得到了五个未描述的代谢物。这些代谢物具有倍半萜烯（+）-4-表-埃里莫芬-9-烯碳骨架，与植物抗毒素capsidiol 互为对映异构体。当真菌受到胁迫时，这些代谢物的分离表明它们可能是 B. cinerea 用来规避植物对植物病原菌化学防御的潜在效应物。这些化合物的生物合成已使用 H 和 C 标记的乙酸盐进行了研究。
